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Table 3 Microsomal heme content and CYP activities in AIP and control livers.

From: Liver Transplantation for Acute Intermittent Porphyria: Biochemical and Pathologic Studies of the Explanted Liver

 

Controls (n = 5)

AIP (n = 1)

Microsomal heme content

0.80 ± 0.26

1.47 ± 0.27

CYP1A2

105 ± 20

116 ± 2.8

CYP2E1

1.26 ± 0.30

1.10 ± 0.09

CYP1A1 + CYP1B1 + CYP3A7

6,049 ± 309

4,498 ± 15

  1. Data are means ± SDs derived from at least two technical replicates. Microsomal heme content is expressed as nmol/mg protein. CYP1A2 activity and the combined activity of CYP1A1, CYP1B1 and CYP3A7 are expressed as relative luciferase units/µg protein, while CYP2E1 activities are expressed as nmol/min/mg protein.
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Molecular Medicine

ISSN: 1528-3658