Association between Fibrillin1 Polymorphisms (rs2118181, rs10519177) and Transforming Growth Factor β1 Concentration in Human Plasma

Table 2 Genotype frequencies and corresponding TGF-β1 values.

FBN1 SNPs	Genotype	Genotype frequency, n (%)	TGF-β1 concentration (ng/mL), minimum/medium/maximum
rs2118181
	AA	192 (71.4)	1.00/6.57/33.12
	AG	64 (23.8)	2.71/7.81/28.08^a
	GG	13 (4.8)	1.40/9.78/17.28^b
	AG + GG	77 (28.6)	1.40/8.02/28.10
rs10519177
	AA	138 (51.3)	1.00/6.40/33.12^c
	AG	73 (27.1)	1.90/5.46/28.08^d
	GG	58 (21.6)	1.40/10.48/27.29
	AG + GG	131 (48.7)	1.40/7.6/28.08

^aTGF-β1 concentration compared with rs2118181 AG versus AA genotypes, p = 0.024. ^bTGF-β1 concentration compared with rs2118181 GG versus AA genotypes, p = 0.094. ^cTGF-β1 concentration compared with rs10519177 AA versus GG genotypes, p < 0.0001. ^dTGF-β1 concentration compared with rs10519177 AG versus GG genotypes, p < 0.0001.

ISSN: 1528-3658