Figure 6

Female-dominant PH in homozygous SM22-Cre, STAT5a/b^−/− mice after chronic hypoxia. Female homozygous knockout mice developed highest mean right ventricular systolic pressure (RVSP) measured by Millar catheterization (A), greatest right ventricular hypertrophy (B) measured by the Fulton index (right ventricle weight/(left ventricle weight + septum weight)), and greatest PA remodeling (C: wall thickness; D: SMA positive vessels per 10× field; and E: elastin staining using Verhoeff-van Gieson stain); scale bar = 45 µm. Wt and KO mice were matched littermates (n = 5/group). *P < 0.05 (adapted from ref. (28)).