Figure 7

Marked reduction of STAT5, PY-STAT5 and BCL6 in cells in obliterative lesions in IPAH patients. Compiled figure adapted from ref. (28) summarizing data from two studies based on lung sections provided by the Department of Pathology, The Johns Hopkins School of Medicine (JHU) and the Pulmonary Hypertension Breakthrough Initiative (PHBI). The top half of this composite summarizes immunofluorescence data from study 1 showing loss of STAT5a (red) in SMA-positive (green) cells in obliterative lesions in IPAH. Quantitation of images in (A) is shown in (B) (mean ± standard error of the mean (SE)), and various controls are shown in (C) and (D). Scale bar = 45 µm. The bottom half of this composite summarizes study 2 in terms of the quantitation of immunofluorescence data for STAT5a + b, PY-STAT5 and BCL6 (mean ± SE) in obliterative lesions in male and female patients. *P < 0.05.