Figure 6From: MicroRNA-15a/16 Regulates Apoptosis of Lung Epithelial Cells After Oxidative StressSuppression of miR-15a/16 promoted apoptosis in lung epithelial cells via both intrinsic and extrinsic pathways (schema). Hyperoxia induced miR-15a/16 expression in lung epithelial cells via ROS generation. Suppression of miR-15a/16 promoted FADD/caspase-8-associated DISC formation. On the other hand, miR-15a/16 deficiency activated caspase-9 via decreased Bcl-2. Thus, suppression of miR-15a/16 promoted caspases-mediated apoptosis in lung epithelial cells, in response to hyperoxia.Back to article page