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Table 2 IC50 values µmol/L using NXT629 (inhibition in antagonist mode) for human nuclear hormone receptors?

From: A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo

PPARα

PPARδ

PPARγ

ERβ

GR

TRβ

0.077 ± 35

6.0 ± 3.2

15 ± 19

12 ± 8

26 ± 21

57 ± 27

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Molecular Medicine

ISSN: 1528-3658