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Figure 2 | Molecular Medicine

Figure 2

From: Early and Short-term Triiodothyronine Supplementation Prevents Adverse Postischemic Cardiac Remodeling: Role of Transforming Growth Factor-β1 and Antifibrotic miRNA Signaling

Figure 2

Effect of T3 treatment on interstitial myocardial fibrosis 14 d after LAD occlusion. (A) Representative Masson trichrome staining in cardiac sections from I/R-L (left) and I/R-L+T3 (right) rats at 14 d after LAD occlusion. The bright blue dotted boxes outline the correspondent region at high magnification. The dotted black line outlines the representative boundaries of AAR and the dividing line between anterior (AARa) and posterior (AARp) regions of AAR. Low magnification (1.25×): 2-mm calibration bar. High magnification (10×): 40-µm calibration bar. (B) Quantitative analysis of interstitial fibrosis measured in the whole LV section (AAR + remote zone) expressed as percentage of the total LV section area. (C, D) Quantitative analysis of the percentage of interstitial fibrosis in the anterior and posterior regions of AAR, respectively, of both groups. In (B–D), data are expressed as the mean ± SEM; n = 3 in each group. Scale bar = 2 mm.

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Molecular Medicine

ISSN: 1528-3658