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Figure 3 | Molecular Medicine

Figure 3

From: Early and Short-term Triiodothyronine Supplementation Prevents Adverse Postischemic Cardiac Remodeling: Role of Transforming Growth Factor-β1 and Antifibrotic miRNA Signaling

Figure 3

Effect of T3 infusion on post-MI TGFβ1 and antifibrotic miRNAs at 3- and 14-d endpoints. (A) TGFβ1 expression and protein level. When compared with sham, TGFβ1 expression (left) and protein levels (right) measured in the I/R-L rats at 3 d post-I/R were upregulated and tended to normalize at 14 d post-I/R. In the I/R-L+T3 group, TGFβ1 mRNA (left) and protein level (right) were in the normal range at both the 3- and 14-d endpoints. (B) miRNA mean value. Compared to sham, miR-133a, miR-30c and miR-29c were significantly decreased at 3 d in the I/R-L group; at 14 d, miR-133a and miR-30c were still downregulated, whereas miR-29c returned to sham level. No alterations were observed at any time point in the I/R-L+T3 group. (C) TGFβ1-miRNA regression plot. n = 4 in each group for (A), right plot; n = 6 in each group for all the other panels. *p ≤ 0.0003 versus sham; #p ≤ 0.002 versus I/R-L+T3 at the 3- and 14-d endpoints.

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Molecular Medicine

ISSN: 1528-3658