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Figure 4 | Molecular Medicine

Figure 4

From: Early and Short-term Triiodothyronine Supplementation Prevents Adverse Postischemic Cardiac Remodeling: Role of Transforming Growth Factor-β1 and Antifibrotic miRNA Signaling

Figure 4

Effect of T3 infusion on MMP-2 and CTGF at 3- and 14-d endpoints. With respect to sham, at 3 d, the I/R-L group showed increased CTGF expression (A, left) and MMP-2 expression (B, left), in the presence of unchanged CTGF content (A, right) and raised MMP-2 protein level (B, right). In the same group, at 14 d, CTGF and MMP-2 expression (A and B, left) and protein level (A and B, right) remained upregulated. Compared to sham, no alterations were observed at any time point in the I/R-L+T3 group except for a small surge in the 14-d CTGF protein, which remained significantly lower than in the corresponding I/R-L group. n = 6 in each group for (A) and (B); n = 4 in each group for (C) and (D). *p ≤ 0.0006 versus sham; #p ≤ 0.002 versus 3- and 14-d I/R-48 h T3; §p ≤ 0.0001 versus all other groups; †p ≤ 0.004 versus all other groups.

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Molecular Medicine

ISSN: 1528-3658