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Figure 5 | Molecular Medicine

Figure 5

From: Early and Short-term Triiodothyronine Supplementation Prevents Adverse Postischemic Cardiac Remodeling: Role of Transforming Growth Factor-β1 and Antifibrotic miRNA Signaling

Figure 5

Effect of T3 treatment on α/β MHC isoform ratio and SERCA2a expression within the AAR. (A) Compared with sham, the I/R-L group showed a reduced α/β MHC ratio at both 3- and 14-d endpoints. In the I/R-L+T3 group, the MHC ratio was increased with respect to sham at 3 d and returned at control level at 14 d. (B) At the 3-d endpoint, the I/R-L rats showed a reduction of SERCA2a expression below the control level; gene expression remained low also at 14 d. With respect to sham, T3 administration increased SERCA2a expression at the 3-d endpoint, while favoring the maintenance of control level at 14 d. n ≥ 5 in each group, *p < 0.0001 versus sham, #p ≤ 0.003 versus I/R-L+T3 at 3 and 14 d post-I/R.

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Molecular Medicine

ISSN: 1528-3658