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Figure 1 | Molecular Medicine

Figure 1

From: Detection and Clinical Significance of Circulating Tumor Cells in Colorectal Cancer—20 Years of Progress

Figure 1

Intravasation of tumor cells into the bloodstream: some at least survive immune destruction and are capable of seeding metastases in distant organs. Hybrid cell refers to a cell transitioning between an epithelial and mesenchymal phenotype. Image reproduced by permission of the European Society of Medical Oncology (Lugano, Switzerland) from reference (33): PK Grover, AG Cummins, TJ Price, IC Roberts-Thomson, and JE Hardingham. Circulating tumour cells: the evolving concept and the inadequacy of their enrichment by EpCAM-based methodology for basic and clinical cancer research. Annals of Oncology. 2014;25(8):1506–1516.

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Molecular Medicine

ISSN: 1528-3658