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Figure 1 | Molecular Medicine

Figure 1

From: Deletion of β-Arrestin2 in Mice Limited Pancreatic β-Cell Expansion under Metabolic Stress through Activation of the JNK Pathway

Figure 1

βarr2 deficiency results in impaired glucose metabolism and glucose-stimulated insulin secretion in mice under HFD. (A) GTT from 16-wk-old HFD-fed MIP-TF-βar2+/+ and MIP-TF-βarr2−/− mice (n = 6). Insets, area under the curve during GTT. (B) Fasting glucose levels of MIP-TF-βarr2+/+ and MIP-TF-βarr2−/− mice fed a HFD. (C) Fasting insulin levels and 15 min after glucose-stimulated insulin secretion levels of 16-wk-old HFD-fed MIP-TF-βarr2+/+ and MIP-TF-βarr2−/− mice (n = 8). *P < 0.05, **P < 0.01, versus MIP-TF-βarr2+/+ mice.

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Molecular Medicine

ISSN: 1528-3658