Figure 2

Dynamic changes of β-cell mass in MIP-TF-βarr2^−/− mice. (A, B) MIP-TF-βarr2^+/+ and MIP-TF-βarr2^−/− mice fed either (A) a chow diet or (B) a HFD were imaged at 4, 8, 12, 16 and 20 wks. Representative bioluminescence images of MIP-TF-βarr2^+/+ and MIP-TF-βarr2^−/− mice are shown. (C, D) Quantification of signal intensity corresponding to the pancreatic area in MIP-TF-βarr2^+/+ and MIP-TF-βarr2^−/− mice (n = 4−6). *P < 0.05 versus MIP-TF-βarr2^+/+ mice.