Figure 1From: BACE-1, PS-1 and sAPPβ Levels Are Increased in Plasma from Sporadic Inclusion Body Myositis Patients: Surrogate Biomarkers among Inflammatory MyopathiesNormal and abnormal cleavage of the amyloid precursor protein. Both pathways are physiologic, but an increase in the abnormal pathway mediated by BACE-1 and PS-1 leads to amyloid-β oligomerization and the accumulation of amyloid-β plaque.Back to article page