Figure 1

Constitutive (A, C) and adult (B) CDH13 knockout alters conditioned place preference (A, B) but not conditioned taste aversion (C) provided by modest to moderate cocaine doses. (A, B) Mean difference ± SEM in time spent on the cocaine-paired side before and after conditioning (n = 1−12/group). There was no significant difference between genotypes in time spent on the drug-paired side during the pre-tests for constitutive (ANOVA, p = 0.740) or conditional (p = 0.542) knockouts. (C) Preference for cocaine-paired saccharin solution in two bottle testing after taste aversion conditioning. *p < 0.05, **p < 0.01.