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Figure 1 | Molecular Medicine

Figure 1

From: Therapeutic Effect of Ergotope Peptides on Collagen-Induced Arthritis by Downregulation of inflammatory and Th1/Th17 Responses and Induction of Regulatory T Cells

Figure 1

Screening for ergotope peptides. Twenty-five overlapping peptides and three control peptides (abbreviated C-1, C-2 and C-3), each containing 20 amino acids, were designed according to the amino acid sequence of murine CD25 (interleukin-2 receptor a chain, IL-2Rα) and CD132 (interleukin-2 receptor γ chain, IL-2Rγ). CD4 + T cells were isolated from the draining lymph nodes of TCV-treated mice at d 45 and then stimulated with different peptides at a dose of 10 µg/mL in the presence of APC for 48 h. IL-10 + cells were detected by ELISPOT assay. Triplicate wells were used. *: P < 0.05 versus controls. Data are representative of three separate experiments with similar results.

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Molecular Medicine

ISSN: 1528-3658