Redox Imbalance in Lung Cancer of Patients with Underlying Chronic Respiratory Conditions

Table 4A A Markers with predictive value in blood for LC-COPD with respect to LC patients.

	ROC^a area (95% CI)	Best cutoff	Sensitivity^b (%) (95% CI)	Specificity^b (%) (95%CI)	NPV^b (%) (95% CI)	PPV^b (%) (95% CI)
Superoxide anion	0.655 (0.517–0.793)	3.56 nmol/L	69.2 (53.6–81.4)	100 (84.5–100)	43.8 (30.7–57.7)	100 (75.8–100)
Protein carbonylation	0.797 (0.683–0.991)	0.56 nmol/mg	54.2 (41.7–66.3)	94.4 (74.2–99.0)	38.6 (25.7–53.4)	97.0 (84.7–99.5)
Nitrotyrosine	0.682 (0.542–0.821)	42.88 nmol/L	65.2 (50.8–77.3)	70.0 (48.1–85.5)	46.7 (30.2–63.9)	83.3 (68.1–92.1)

^aROC curve area in blood for LC-COPD with respect to LC patients. ^bSensitivity, specificity, PPV and NPV, all expressed as percentage, with 95% CI, were calculated in all patients with LC-COPD (N = 59) for the best cutoff points of the study variables with respect to LC patients without COPD (N = 21).

ISSN: 1528-3658