Figure 1

Design of the study. (A) Diagram of the timeline for the experiments in this study. Male C57BL/6 mice are subjected to cecal ligation and puncture (CLP) or sham surgery on d 1, which is followed by the indicated procedures. (B) Kaplan-Meier survival curve showing that some CLP-exposed mice perish within the first week post-surgery before the rest reach a stable survival rate of 56% by d 11. (C) The box plot shows body weights at 35 d post-surgery, which are not significantly different between groups (P = 0.029, t = 2.24, t test). (D) The graph describes the scores for the functions in the observational screen, as defined in Materials and Methods. All functions are comparable between CLP and sham groups (P > 0.1 for each function by t test). AF, autonomic function; SF, sensory function; SCF, spinocerebellar function; MMF, muscle and motoneuron function; NPF, neuropsychiatric function.