Figure 6

Altered dendritic spine density of DG neurons in CLP-exposed mice. (A) Traces of representative Golgi-stained dentate neurons from the sham and CLP groups. (B) The graph shows the length of DG dendrites (obtained from Sholl analysis) versus distance from the cell body. Values are not significantly different between groups (ns, not significant; P = 0.98, D = 0.14, Z = 046, Kolmogorov-Smirnov test). (C) The graph shows that the cumulative probability of the distribution of primary dendrites for both groups is comparable (inset shows box plots; ns, P = 0.47, t test). (D-E) Box plots of dendritic measurements are comparable for total length (D, ns, P = 0.09, t test) and mean length (E, ns, P = 0.18, t test). (F) Micrographs show dendritic spines in DG dendrites. (G) The box plot of spine density shows that the CLP group has significantly fewer spines than the sham group. Statistics, * P < 0.05 by t test.