Genome-Wide Association Study of Late-Onset Myasthenia Gravis: Confirmation of TNFRSF11A and Identification of ZBTB10 and Three Distinct HLA Associations

Table 1 Subgrouping of MG patients in previous studies.

	EOMG	LOMG	Thymoma-MG
MG onset age (years)	10–40, 50 or 60 (puberty to menopause)	>40, >50 or >60	>10
Female:male	≥ 3:1	1:1.7	1:1
Thymic histology	Medullary lymph node-like infiltrates (>80%)	Atrophy/normal-for-age	Epithelial neoplasm
Autoantibodies (at diagnosis)
AChR	100% by definition	100% by definition	≤100%
Titin	<5%	>70%	>95%
IFN-α and/or IL12	<5%	∼60%	>70%
HLA associations (references)	DQ2-DR3-B8-A1: especially in females (10,15)	DR15 (6); DR2/B7 in males (10); DR7 if titin-Ab⁺ (12)	None confirmed

The summary is based on studies of European patients. The specific autoantibodies are rare in other diseases, apart from those against IFN-α values, which are found in ≤100% of patients with autoimmune polyendocrine syndrome type 1 (5).

ISSN: 1528-3658