Figure 8
Effect of the combined treatment on cardiac contractile function in aged septic rats. Rats were sham operated or subjected to CLP with injection of vehicle (normal saline) or GG-2 (80 nmol/kg of ghrelin and 50 µg/kg of GH) at 5 h after CLP. At 20 h after CLP, rats were anesthetized, and left ventricular pressure measurements and heart rate were recorded using a Millar pressure transducer. (A) LVDP, (B) maximal rate of ventricular pressure development (+dP/dtmax) and (C) work product were calculated. Data are expressed as mean ± SE (n = 5–7 per group). *P < 0.05 versus sham and #P < 0.05 versus vehicle.