Figure 1

Alteration in body weight, food intake and insulin sensitivity in PPARγ2KO mice during pregnancy. (A) Evolution of body weight in pregnant mice with deletion of PPARγ2 (PPγ2KO-P) and in corresponding pregnant WT (WT-P) animals. (B) Changes in food intake during pregnancy. Food intake was measured every 24 h. Data from the first, second and third phase of pregnancy are shown. (C) GTT curves from nonpregnant and pregnant WT mice, (D) from nonpregnant and pregnant PPγ2KO mice and (E) from pregnant WT and PPγ2KO mice. All mice were at d 15 of gestation. (F) ITT curves from pregnant WT and PPγ2KO mice at d 16 of gestation. Data are expressed as mean ± SEM (A, B: n = 10–15 animals/group; C–F: n = 9–11 animals/group). *p ≤ .05.