Figure 5

Expression levels of genes involved in hepatic lipid metabolism and morphological changes of the pancreas in the PPγ2KO mouse at late pregnancy. (A) mRNA levels of hepatic lipid metabolism genes in pregnant and nonpregnant WT and PPγ2KO mice (n = 6 animals/group). † p ≤ .05 pregnant versus non pregnant; # p ≤ .05 PPγ2KO-P versus WT-C; § p ≤ .05 PPγ2KO-C versus WT-C; * p ≤ .05 PPγ2KO-P versus WT-P. (B) Average area of the islets relative to total area of the analyzed pancreatic section in each group (A.U.: arbitrary units). (C) Representative images of insulin (red), CHOP (green) and nucleus (blue) immunohistochemistry in islets from pregnant WT and PPγ2KO mice (n = 4 animals/group). Arrows indicate colocalization of insulin and CHOP. Merged show original magnification × 400. Scale bar: 50 µm.