Figure 6

Role of PPARγ2 in the different adipose tissue depots during late pregnancy. Pregnant WT mice can expand both perigonadal and subcutaneous fat, inducing physiological insulin resistance and adaptation of β-cell mass. The absence of PPARγ2 in mouse perigonadal and subcutaneous fat, liver, muscle and β-cells during pregnancy results in inflammation associated with a lack of expansion of perigonadal fat, compromised subcutaneous fat and increased deposition of lipids in the liver, leading to marked peripheral insulin resistance and impaired β-cell mass. Inflammation shown as macrophages surrounding dying or dead adipocytes, detected as crown-like structures. Adipocyte-derived epithelial cells are shown in subcutaneous fat depot during pregnancy. TGs: triacylglycerides; Ins: insulin; IR: insulin resistance.