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Figure 3 | Molecular Medicine

Figure 3

From: Low MiR-187 Expression Promotes Resistance to Chemoradiation Therapy In Vitro and Correlates with Treatment Failure in Patients with Esophageal Adenocarcinoma

Figure 3

MiR-187 modulates radiosensitivity and cisplatin sensitivity in EAC cells. MiR-187 was transiently overexpressed in EAC cells, and the effect of 2 Gy X-ray radiation or 1 µM cisplatin was assessed by clonogenic assay. (A) Transient overexpression of miR-187 significantly sensitized OE33P and OE33 R cells to 2 Gy radiation when compared with scrambled vector control (miR-VC). (B) Transient overexpression of miR-187 significantly sensitized SK-GT-4 cells to 2 Gy radiation when compared with scrambled vector control (miR-VC). (C) Transient overexpression of miR-187 significantly sensitized OE33 cells to 2 Gy radiation when compared with a scrambled control. (D) Transient overexpression of miR-187 significantly sensitized OE33 cells to cisplatin when compared with a scrambled vector control. Statistical analysis was performed using (A) OE33 P paired t-test and OE33 R Wilcoxon matched pairs test (B and D) paired test and (C) unpaired t test; *p < 0.05, **p < 0.01.

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Molecular Medicine

ISSN: 1528-3658