Figure 2

BAFF-R-Ig treatment depletes naive B cells. (A, C) Frequency of each B-cell subset as a percentage of total lymphocytes in NZW/BXSB male (A) and NZB/W female (B) chimeras. Four to eight mice were examined per group (*p < 0.05; †p < 0.01; ‡p < 0.001). (B, D) Total number of B cells in each subset per spleen. n = 4–8 per group; *p < 0.05; †p < 0.01; †p < 0.001, 3H9 untreated versus 3H9 BAFF-R-Ig-treated chimeras (T1, T2, transitional type 1 and 2 B cells; MZ, marginal zone; FO, follicular; CS, class switched; PC, plasma cell).