Figure 6

Distribution of Jκ regions among Vκ5-45- and Vκ5-48-encoded light chains as a percentage of total GC light chains is shown in NZW/BXSB (A) and NZB/W (B) chimeras. The ratio of the two dominant light chains Vκ5-43/45/Jk5 and Vκ5-48/Jκ4 is reversed in NZW/BXSB mice treated with BAFF-R-Ig (‡p < 0.01). C-E show the mutation frequency per sequence for NZW/BXSB Vκ5-43 (C), NZB/W Vκ5-43 (D) and NZB/W Vκ5-48 (E).