Spautin-1 Ameliorates Acute Pancreatitis via inhibiting impaired Autophagy and Alleviating Calcium Overload

Table 2 Histopathological change of pancreatic tissues in the mice model with acute pancreatitis induced by L-arginine.

Parameter	Group 4	Group 5	Group 6	P value*
Edema degree	1.50±0.58	3.75±0.5	2.75±0.5	0.001/0.03
Inflammation degree	0.50±0.58	3.50±0.58	2.00±0.82	<0.001/0.027
Vacuolization degree	0.00±0.00	2.25±0.96	2.25±0.96	0.003/1.00
Necrosis degree	0.00±0.00	2.75±0.50	1.25±0.50	<0.001/0.05
Total score	2.00±0.82	12.25±2.36	8.25±0.96	0.002/0.035

*The P value indicates the statistical significance for the differences among Group 4 and 5/among Group 5 and 6.
Group 4: saline control; Group 5: mice injected with L-arginine; Group 6: mice injected with L-arginine together with spautin-1.

ISSN: 1528-3658