Figure 1
From: T regulatory Cell-mediated Immunotherapy for Solid Organ Transplantation: A Clinical Perspective
Development of Tregs and immune balance. (A) Treg develops from naïve CD4+ T cell population under the influence of IL-4 and IL-2 and characterized by surface expression of CD25 and nuclear expression of FOXP3 compared to other T cell lineages. (B) Immune balance between Tregs (graft-protective cells) and T-effector cells (graft-destructive cells) modulate the effective immune response and immunotolerance to foreign antigens.