Figure 3From: T regulatory Cell-mediated Immunotherapy for Solid Organ Transplantation: A Clinical PerspectiveTreg therapy and immunotolerance. This demonstrates ex vivo and in vivo expansion of freshly isolated Tregs for cell therapy to rescue allograft rejection. Adoptive transfer of Tregs shows downregulation of CD4+ T cells followed by upregulation of Th2 responses, which favor microvascular and tissue repair in rejecting allograft.Back to article page