Figure 3

Local enrichment of EERMs and epigenetic modification. EERMs (green balls) can be produced in both the cytoplasm and nucleus, depending on the distribution of the EERM-producing enzymes. The EERM-producing enzymes localized in the nucleus may increase the enrichment of EERMs locally, facilitating the global regulation of epigenetic modifications by the EERM-dependent epigenetic modifiers. The EERM-producing enzymes may also form complexes with EERM-dependent epigenetic modifiers and/or gene-specific transcription factors and provide a local supply of EERMs to gene-specific regulation of epigenetic modifications.