Figure 5
From: Superoxide induces Neutrophil Extracellular Trap Formation in a TLR-4 and NOX-Dependent Mechanism
Proposed model of NET induction by extracellular superoxide. (A) Schematic representation of superoxide (O2−) generation during and elements of the NET-promoting cascade. During liver I/R, membrane-nonpermeable superoxide functions to activate TLR-4 signaling pathways, which subsequently activates NOX, leading to induction of NETs. Membrane-permeable hydrogen peroxide (H2O2) propagates NET formation without activation of NOX.