Figure 2
From: Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile sepsis Model
Aerobic and anaerobic bacterial colony counts and neutrophil counts from peritoneal lavage samples after cecal slurry injection. (A) MMP8 null animals (n = 13) had a higher aerobic bacterial burden 18 h after cecal slurry injection, compared with that found in the peritoneal lavage of wild-type animals (n = 10, experiment performed 2 times). *p < 0.05 by 2-tailed t test. (B) Similarly, anaerobic bacterial burden was greater in peritoneal lavage of MMP8 null animals (n = 19) 18 h after cecal slurry injection compared with that of wild-type animals (n = 20, experiment performed 3 times). *p < 0.05 by 2-tailed t test. (C, D) Neutrophil counts in the corresponding peritoneal lavage samples tended to be higher in MMP8 null mice at 6 h (C) and 18 h (D), but were not statistically different. All data reported as mean ± SEM.