Figure 5
From: Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile sepsis Model
Net formation after cecal slurry. (A) Representative image from wild-type animals treated with cecal slurry. Histone H4 (blue) co-localized with DNA (green), with neutrophil elastase (red) present both in degenerating neutrophils and along DNA NETs. (B) Six hours after cecal slurry, both wild-type and MMP null mice had an increased percentage of DNA signal outside the nucleus; however, there was no difference between wild-type (n = 10) and MMP8 null animals (n = 10). *p < 0.05 versus respective sham injected animals. All data reported as mean ± SEM. White bars represent sham-injected mice and black bars represent slurry-injected mice.