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Figure 2 | Molecular Medicine

Figure 2

From: Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

Figure 2

Hpx−/− sickle mice develop more stasis than Hpx+/+ sickle mice following heme infusion. NY1DD bone marrow (BM) was transplanted into C57BL/6 Hpx+/+ and C57BL/6 Hpx−/− mice (n = 3). Twelve weeks after BM transplant (BMT), plasma Hpx levels were examined on western blot (A) and microvascular stasis was measured in a DSFC at 1 h and 4 h after infusion of 3.2 µmols/kg of heme (B). Percentage of stasis (mean ± SD) was calculated at 1 h and 4 h after heme infusion. *P < 0.025 NY1DD Hpx+/+ versus NY1DD Hpx−/−.

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Molecular Medicine

ISSN: 1528-3658