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Figure 4 | Molecular Medicine

Figure 4

From: Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

Figure 4

Hemopexin gene therapy inhibits heme-induced microvascular stasis in sickle mice. NY1DD (A) and Townes-SS (B) mice were hydrodynamically infused with lactated Ringer’s solution (LRS), SB100X + Luc, or SB100X + wt-Hpx [NY1DD (n = 4) and Townes-SS: LRS and wt-Hpx (n = 3) and Luc (n = 2)]. DSFCs were implanted 4 wks later and microvascular stasis was measured at 1 h and 4 h after infusion of heme (3.2 µmols/kg). Percentage of stasis (mean ± SD) was calculated at each time point. *P < 0.05 for wt-Hpx compared with LRS.

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Molecular Medicine

ISSN: 1528-3658