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Figure 5 | Molecular Medicine

Figure 5

From: Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

Figure 5

Hemopexin gene therapy increases Nrf2, LRP1/CD91 and heme oxygenase-1 (HO-1) expression in the livers of NY1DD sickle mice. NY1DD mice were hydrodynamically infused with lactated Ringer’s solution (LRS), SB100X + Luc or SB100X + wt-Hpx (n = 4). Livers were harvested 4 wks later after measurement of heme-induced stasis and used for western blots. (A) Liver nuclear extracts were immunostained for (A) Nrf2 (MW 98 kDa), and liver microsomes were immunostained for (B) the hemopexin receptor (CD91/LRP1, 91 kDa), (C) HO-1 (32 kDa) and (D) a GAPDH (32 kDa) loading control.

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Molecular Medicine

ISSN: 1528-3658