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Figure 6 | Molecular Medicine

Figure 6

From: Mutations in the Na+/Citrate Cotransporter NaCT (SLC13A5) in Pediatric Patients with Epilepsy and Developmental Delay

Figure 6

Homology model of hNaCT showing the location of the point mutations. (A) Y82 is located in TM4, (B) G219 (TM5a), (C) T227 (TM5b) and (D) L488 and L492 (both located in TM10). In all panels, the transmembrane helices are shown as cyan cartoons; key amino acids represented by sticks with the mutated residues colored in orange. The purple sphere in panels (B) and (C) represents the sodium ion that binds the Na1 binding site. Citrate is shown in green sticks in panel (C).

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Molecular Medicine

ISSN: 1528-3658