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Figure 1 | Molecular Medicine

Figure 1

From: Integration of Known DNA, RNA and Protein Biomarkers Provides Prediction of Anti-TNF Response in Rheumatoid Arthritis: Results from the COMBINE Study

Figure 1

A) Overview of study design and cohort setup. B) DAS28-CRP score stratified by cohort and visit time, with an assumed value of 0 for the HC cohort. Each dot shows one sample. The Y-axis shows DAS28-CRP level and the X-axis shows cohort membership and time point. Grey lines connect paired time-points, and horizontal black bars indicate median value. Color-coding corresponds to figure 2C. C) Reproducibility of RNA-seq expression levels from technical replicates, in different library preparations with three months separation. Each dot shows the read count of one single gene. The Pearson correlation coefficent of log transformed counts was 0.991 (P<2e-16). D) Principal components analysis of genome-wide genotype profile and self-reported country of origin of individuals. Each dot shows one patient, color-coded by self-reported country of origin. TNFi: TNF inhibitor, MTX: Methotrexate, Rx naïve: no methotrexate initation.

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Molecular Medicine

ISSN: 1528-3658