Figure 6
From: Deficiency of α7 Nicotinic Acetylcholine Receptor Attenuates Bleomycin-Induced Lung Fibrosis in Mice
Changes of BAL profiles and lung arginase 1+ Ly6C+ cells at d 7 with low-dose BLM challenge. (A, B) BAL leukocytes and protein levels at d 7 with low-dose BLM challenge. Chrna7+/+ and Chrna7−/− mice were intratracheally challenged with BLM (0.5 mg/kg) and euthanized at d 7. Saline-challenged Chrna7+/+ mice were used as controls. N = 3–5. **p < 0.01 in compared groups. (C, D) Flow cytometry analysis of lung arginase 1+ Ly6C+ cells at d 7 with low-dose BLM challenge. Chrna7+/+ and Chrna7−/− mice were intratracheally challenged with BLM (0.5 mg/kg) and euthanized at d 7 d. Saline-challenged Chrna7+/+ mice were used as controls. The lung cells were isolated by digestion. The cells in the whole cell gate were analyzed by Flowjo software. The percentage of arginase 1+Ly6C+ cells is shown. N = 3–5. *p < 0.05 between compared groups.