Figure 2
Tau45-230 was also detected in the precentral gyrus of ALS subjects. (A) Quantitative Western blot analysis of tau content in representative homogenates prepared from postmortem samples of precentral gyrus from control (C) and ALS (ALS) subjects. Immunoreactive bands at 17 kDa apparent molecular weight corresponding to tau45-230 were readily detectable in some ALS samples. (B) Graphs show the ratios of tau45-230/full-length tau in control and ALS subjects. Numbers represent the mean ± SEM of control (n = 9) and ALS tau45-230 positive (n = 10) samples. Values are expressed as percentage of controls, considering the values obtained in control subjects as 100%. ALS Class III β tubulin (TUJ1) was used as loading control. *Differs from control subjects; P < 0.01.