Figure 10

Effect of YD0171 on the cell cycle of HCT116 cells. Cells were treated with YD0171 (100),300,1 mmol/L), or the positive control nocodazole for 48 h, followed by flow cytometric cell cycle analysis. Typical profiles are shown in the gray panels; cell cycle distributions are shown by the bagel charts. Although nocodazole induced the expected G1 cell cycle arrest, YD0171 or AOAA did not induce cell cycle arrest but increased the G1 phase and reduced the G2 phase. Data shown are representative of n = 3 determinations.