Figure 16
YD0171 inhibits H2S production in HCT116 tumors of nude mice. Mice were subjected to implantation of PDTX of a colon cancer patient. When the tumor reached the size of 1,000 mm3, treatment with vehicle or YD0171 (3 mg/kg/d) started and continued for 7 d, at which point tumors were excised and liver tissues were collected. Tissues were homogenized and CBS-mediated H2S production was measured by the AzMC method. CBS activity was reduced by YD0171 (*p < 0.05) in the tumor tissue, but no significant inhibition was detected in the liver tissue. Data are shown as mean ± SEM values of n = 4 animals per group.