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Figure 2 | Molecular Medicine

Figure 2

From: Cystathionine-β-Synthase Inhibition for Colon Cancer: Enhancement of the Efficacy of Aminooxyacetic Acid via the Prodrug Approach

Figure 2

Effect of AOAA and YD0171 on the H2S-synthesizing activity of human recombinant full-length CBS enzyme. AOAA concentration dependently inhibited H2S production (detected by the AzMC method) with an IC50 of ∼2 µmol/L, while YD0171 was a substantially weaker direct inhibitor of recombinant CBS activity (IC50: ∼300 µmol/L). Data shown as mean ± SEM; n = 3.

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Molecular Medicine

ISSN: 1528-3658