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Table 1 Effect of covalent modifications of AOAA on recombinant CBS activity in vitro.

From: Cystathionine-β-Synthase Inhibition for Colon Cancer: Enhancement of the Efficacy of Aminooxyacetic Acid via the Prodrug Approach

Compound

Structure

CBS activity (% of control) at 100 µmol/L

AOAA

10 ± 3

YD0135

114 ± 5

YD0151

91 ± 2

YD0154

74 ± 5

YD0163

163 ± 12

YD0164

83 ± 9

YD0177

92 ± 3

YD0196

108 ± 11

YD0197

94 ± 3

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Molecular Medicine

ISSN: 1528-3658