Table 3 Metabolomic effects of AOAA and YD0171: enrichment analysis. Clusters with >5 measured metabolites are presented. Concordance is calculated as the % of metabolites affected by AOAA that are also affected by YD0171 for clusters where more metabolites were affected by AOAA than YD0171 and concordance is calculated as the % of metabolites affected by YD0171 that are also affected by AOAA for clusters where more metabolites were affected by YD0171 than AOAA.

TCA cycle

8

7 (88)

7 (88)

100

Polyamine metabolism

7

6 (86)

4 (57)

67

Phospholipid metabolism

43

33 (77)

23 (53)

70

Plasmalogen

10

7 (70)

5 (50)

71

Glutamate metabolism

10

6 (60)

6 (60)

100

Nicotinate and nicotinamide metabolism

10

6 (60)

7 (70)

86

Alanine and aspartate metabolism

6

4 (67)

4 (67)

100

Fatty acid metabolism

22

13 (59)

9 (41)

69

Pyrimidine metabolism

26

15 (58)

17 (65)

88

Sphingolipid metabolism

26

15 (58)

7 (27)

47

Leucine, isoleucine and valine metabolism

21

12 (57)

7 (33)

53

Purine metabolism

35

20 (57)

18 (51)

90

Nucleotide sugar

7

4 (57)

3 (42)

80

Histidine metabolism

9

5 (56)

5 (56)

100

Vitamin B6 metabolism

6

3 (50)

3 (50)

100

γ-Glutamyl amino acid

13

6 (46)

5 (38)

83

Glycolysis, gluconeogenesis and pyruvate metabolism

11

5 (45)

3 (27)

60

Glutathione metabolism

9

4 (44)

4 (44)

100

Methionine, cysteine, SAM and taurine metabolism

18

8 (44)

4 (22)

50

Pentose metabolism

7

3 (43)

2 (29)

67

Lysine metabolism

10

4 (40)

2 (20)

50

PUFA metabolism

13

5 (38)

3 (23)

60

Urea cycle

14

5 (38)

7 (50)

71

Dipeptide

18

6 (33)

6 (33)

83

Phenylalanine and tyrosine

10

3 (30)

1 (10)

33

Glycine, serine and threonine

7

2 (29)

1 (14)

50

Aminosugar metabolism

7

1 (14)

1 (14)

100

Lysolipid

26

3 (11)

2 (7)

67