Figure 4
From: Shock Wave Therapy Enhances Angiogenesis through VEGFR2 Activation and Recycling
Shock wave (SW)-induced angiogenesis ex vivo and in vivo. (A) Representative sprouting morphology in ob/ob mice carotid artery with (n = 8) and without (n = 9) SW treatment (scale bar, 200 µm). Upper panel: Original images; Lower panel: Computer-processed images by WimSprout image analysis for sprouting determination. (B) Parameters of sprouting assay, including sprout area and sprout distance. (C) Representative images of laser Doppler flowmetry in ob/ob mice without (CON) and with SW treatment 14 d post-critical limb ischemia (CLI). (D) Measurement of blood flow post-CLI without (CON, n = 9) and with (n = 7) SW treatment by laser Doppler flowmetry. Data presented as mean ± S.D. *P < 0.05 determined by Student t test.