Table 3 Fold changes in NF-κB pathway mRNA gene expression following neutrophil treatment with LPS and LPS/A1AT (Prolastin®) for 4 h.
Gene | A1AT (Prolastin®) | 10 ng/mL LPS | A1AT (Prolastin®) + LPS | ||||||
|---|---|---|---|---|---|---|---|---|---|
N | Mean(SD) | N | Mean(SD) | P | N | Mean(SD) | P* | ||
IKBKB | 3 | 0.9 (0.28) | 3 | 2.4 | (0.53) | 0.04 | 3 | 2.3 (0.73) | NS |
IKBKE/IKKε | 3 | 1.2 (0.61) | 3 | 12.5 | (6.5) | 0.03 | 3 | 8.1 (1.1) | NS |
IKBKG | 3 | 0.77 (0.5) | 3 | 0.8 | (0.47) | NS | 3 | 0.7 (0.1) | NS |
NFKB1/p50 | 3 | 0.87 (0.34) | 3 | 9.5 | (0.46) | 0.001 | 3 | 8.1 (2.6) | 0.004 |
NFKB2/p52 | 3 | 0.59 (0.32) | 3 | 5.9 | (2.8) | 0.023 | 3 | 4.0 (0.9) | NS |
NFKBIB/IkB-β | 3 | 0.76 (0.31) | 3 | 1.8 | (0.54) | 0.002 | 3 | 1.6 (0.1) | 0.017 |
NFKBIA/IkB-α | 3 | 0.99 (0.13) | 3 | 9.4 | (1.2) | 0.001 | 3 | 7.4 (1.6) | NS |
NFKBIE/IkB-ε | 4 | 0.86 (0.52) | 3 | 5.3 | (0.74) | 0.036 | 3 | 4.0 (2.5) | NS |
REL/c-Rel | 4 | 0.63 (0.21) | 3 | 4.2 | (0.41) | 0.001 | 3 | 3.1 (0.92) | NS |
RELA/p65 | 4 | 0.8 (0.28) | 3 | 2.8 | (0.7) | 0.004 | 3 | 1.6 (0.2) | 0.009 |
RELB | 5 | 0.57 (0.33) | 3 | 2.6 | (0.94) | 0.02 | 3 | 1.1 (0.4) | NS |