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Figure 4 | Molecular Medicine

Figure 4

From: Altered Redox Mitochondrial Biology in the Neurodegenerative Disorder Fragile X-Tremor/Ataxia Syndrome: Use of Antioxidants in Precision Medicine

Figure 4

Ethanol metabolism in cells from premutation carriers. Ethanol is normally metabolized to acetate by generating NADH. Excess of [NADH]/[NAD+] promotes lactate formation, inhibits Kreb’s cycle, favors ketogenesis and lipogenesis from excess of acetylCoA that did not enter the Kreb’s cycle. These effects are all compounded in a background exhibiting a mitochondrial dysfunction.

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Molecular Medicine

ISSN: 1528-3658