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Table 1 Clinical and laboratory characteristics of the study participants.

From: Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-κB Activation

Characteristic

Non-SMA (Hb ≥ 5.0 g/dL)

SMA (Hb < 5.0 g/dL)

P*

Number of subjects

93

51

N/A

Age, months

12.03 (10.00)

7.38 (5.77)

0.007a

Gender: male/female **

52/41

22/28

0.676b

Glucose (mMol/L)

4.90 (1.00)

5.10 (1.00)

0.484a

Temperature (°C)

37.40 (2)

37.30 (1)

0.818a

White blood cells (×109/µL)

11.60 (5.70)

14.95 (8.55)

0.005a

Lymphocytes (×103/µL)

49.00 (23.05)

51.05 (12.55)

0.128a

Monocytes (×103/µL)

8.40 (4.90)

10.15 (7.95)

0.037a

Granulocytes (×103/µL)

42.10 (26.00)

37.90 (16.80)

0.051a

Hemoglobin (Hb, g/dL)

7.90 (5.05)

4.20 (1.10)

< 0.0001a

Hematocrit (Hct, %)

23.70 (14.20)

13.05 (3.40)

< 0.0001a

Red blood cells (×106/µL)

3.58 (1.57)

1.85 (0.85)

< 0.0001a

Platelets (×103/µL)

171 (134)

141 (85)

0.042a

Parasite denisty (/µL)

24,991 (54,895)

23,661 (62,758)

0.928a

Pigment-containing monocytes (PCM), n (%)

45 (48.39)

39 (76.47)

0.001b

Pigment-containing neutrophils (PCN), n (%)

6 (6.0)

11 (21.57)

0.007b

PCM (/µL)

10.52 (1.95)

41.25 (7.10)

< 0.0001c

PCN (/µL)

0.34 (0.14)

5.31 (1.88)

< 0.0001c

Reticulocyte production index < 2.0

58 (62.37)

47 (92.16)

< 0.0001a

  1. Parasitemic children (n = 144) were stratified into non-SMA (i.e., Hb ≥5.0 g/dL) and SMA (i.e., Hb <5.0 g/dL) (34). Data presented are medians (interquartile range, IQR), unless otherwise stated. aStatistical significance determined by Mann-Whitney U test. bStatistical significance determined by the Chi-square analysis. cStatistical significance determined by independent samples t test.